Damaros™
Agentic infrastructure for clinical trial execution.
The Trial Rift
Care happens everywhere. The trials that save lives do not.
NCI-designated centers cluster in a few metros while most patients are treated hours away. Trial access follows the map, not the diagnosis, and that gate is unfair by design. Distance is the real exclusion criterion.
The patient who fits sits in a chart no trial will ever read. Eligibility is checked by hand, against memory, if it is checked at all, so the match dies quietly and the trial closes before anyone finds them.
The rare site that tries is drowning in disconnected systems that never talk, with protocol, eligibility, and audit stitched by hand, until the coordinators executing the trial burn out and the site stops saying yes.
Execution Spine
An engine decides. A human signs. Every run rebuilds itself.
Protocol
Intent becomes logic.
The protocol becomes executable law. Criteria, windows, and evidence rules compile once into versioned, locked logic, then deploy byte-identical to every site.
Evidence
Records become evidence.
Site-approved patient data arrives screening-ready, with source lineage, freshness, and mapping. The messy chart becomes admissible input; PHI never meets a model.
Screening
A verdict, not a guess.
A deterministic engine, not a model's opinion. Every criterion runs against locked logic for a PASS, REVIEW, or FAIL with evidence pointers. Anything unclear routes to a human.
Resolve
Judgment, then signature.
Node's accountability layer, standing beside the pipeline. Agents triage, rank, and stage every decision; an accountable human commits, immutable and bound to Replay. Prepared by machines, owned by a person.
Replay
Execution becomes proof.
Reconstruct any run end-to-end: Protocol, Evidence, Screening, Resolve, and who authorized it. Hash-verified, signed, and PHI-free. Not a log you trust, a proof you can replay.
Operations Mesh
The machinery behind governed trial execution.
Trident
Makes protocols executable.
Trident turns criteria, timelines, evidence needs, and ambiguity into clear instructions every site can run the same way.
Luna
Makes AI inspectable.
Luna tracks each suggestion, task, handoff, and output against policy, PHI limits, source evidence, human review, and Replay.
Eye
The execution graph, alive.
Eye makes protocol execution visible as it moves: where sites are ready, where evidence is missing, and where the protocol is creating friction.
Sentinel
Finds hidden protocol opportunity.
Compares PHI-free site evidence facts against enrolling criteria to surface where protocols and site reality overlap. Guarded, replayable, and never a per-patient verdict.
Trial Intelligence
Research embeds where care lives.
Node
Care sites become trial-capable infrastructure.
Node admits site-approved evidence, routes review, and preserves clinician control. The site becomes sponsor-legible without becoming sponsor-controlled.
Hospitals and clinics can execute protocols with evidence, governance, and Replay while operations and patient care stay local.
Console
Reach without operational blindness.
Sponsors see permissioned execution signals from the field: evidence gaps, review burden, criterion friction, amendment pressure, and Replay completeness.
Track site readiness, resolution, failure, and execution drift across the network without raw patient data crossing the boundary.
Cloud, dedicated, institution-hosted, or air-gapped for federal and zero-trust environments.